abstract：:Accumulating evidence indicates that CDK2 promotes hyperproliferation and is associated to poor prognosis in multiple cancer cells. However, the physiological role of CDK2 in GBM and the biological mechanism still remains unclear. In this study, we identified that CDK2 expression was significantly enriched in GBM tumo...

journal_title：Translational oncology

authors： Wang J,Yang T,Xu G,Liu H,Ren C,Xie W,Wang M

更新日期：2016-12-01 00:00:00

abstract：:The JNK and P38α pathways play an important role in the sensitivity and outcomes of chemotherapy. We hypothesize that functional single nucleotide polymorphisms (SNPs) of genes of these pathways modulate outcomes of patients with advanced non-small cell lung cancer (NSCLC) treated with first-line platinum-based chemot...

journal_title：Translational oncology

authors： Jia M,Xu Y,Zhu M,Wang M,Sun M,Qian J,Chang J,Wei Q

更新日期：2016-12-01 00:00:00

abstract：:Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...

journal_title：Translational oncology

authors： Ribatti D,Nico B,Ruggieri S,Tamma R,Simone G,Mangia A

更新日期：2016-10-01 00:00:00

abstract：:The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...

journal_title：Translational oncology

authors： Druliner BR,Rashtak S,Ruan X,Bae T,Vasmatzis N,O'Brien D,Johnson R,Felmlee-Devine D,Washechek-Aletto J,Basu N,Liu H,Smyrk T,Abyzov A,Boardman LA

更新日期：2016-08-01 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...

journal_title：Translational oncology

authors： Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho P

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of...

journal_title：Translational oncology

authors： Murrell DH,Zarghami N,Jensen MD,Chambers AF,Wong E,Foster PJ

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Recurrence of hepatocellular carcinoma can arise from the primary tumor ("early recurrence") or de novo from tumor formation in a cirrhotic environment ("late recurrence"). We aimed to develop one simple gene expression score applicable in both the tumor and the surrounding liver that can predict the recurre...

journal_title：Translational oncology

authors： Dekervel J,Popovic D,van Malenstein H,Windmolders P,Heylen L,Libbrecht L,Bulle A,De Moor B,Van Cutsem E,Nevens F,Verslype C,van Pelt J

更新日期：2016-04-01 00:00:00

abstract：:Prostate cancer (CaP) is the most commonly diagnosed and the second leading cause of death from cancer in males in USA. Prostate orthotopic mouse model has been widely used to study human CaP in preclinical settings. Measurement of changes in tumor size obtained from noninvasive diagnostic images is a standard method ...

journal_title：Translational oncology

authors： Ni J,Cozzi P,Hung TT,Hao J,Graham P,Li Y

更新日期：2016-02-01 00:00:00

abstract：:We have recently shown that centrosomal protein 57 (CEP57) is overexpressed in a subset of human prostate cancers. CEP57 is involved in intracellular transport processes, and its overexpression causes mitotic defects as well as abnormal microtubule nucleation and bundling. In the present study, we further characterize...

journal_title：Translational oncology

authors： Mang J,Korzeniewski N,Dietrich D,Sailer V,Tolstov Y,Searcy S,von Hardenberg J,Perner S,Kristiansen G,Marx A,Roth W,Herpel E,Grüllich C,Popeneciu V,Pahernik S,Hadaschik B,Hohenfellner M,Duensing S

更新日期：2015-12-01 00:00:00

abstract：:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...

journal_title：Translational oncology

authors： Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JP

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:This study presented a three-dimensional magnetic resonance (MR)-based method to separate a breast into four quadrants for quantitative measurements of the quadrant breast volume (BV) and density. METHODS:Breast MR images from 58 healthy women were studied. The breast and the fibroglandular tissue were segment...

journal_title：Translational oncology

authors： Fwu PT,Chen JH,Li Y,Chan S,Su MY

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...

journal_title：Translational oncology

authors： Liu X,Sun X,Liu J,Kong P,Chen S,Zhan Y,Xu D

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS:Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-ech...

journal_title：Translational oncology

authors： Jafari-Khouzani K,Emblem KE,Kalpathy-Cramer J,Bjørnerud A,Vangel MG,Gerstner ER,Schmainda KM,Paynabar K,Wu O,Wen PY,Batchelor T,Rosen B,Stufflebeam SM

更新日期：2015-06-01 00:00:00

abstract：:Adequately selecting a therapeutic approach for bladder cancer depends on accurate grading and staging. Substantial inaccuracy of clinical staging with bimanual examination, cystoscopy, and transurethral resection of bladder tumor has facilitated the increasing utility of magnetic resonance imaging to evaluate bladder...

journal_title：Translational oncology

authors： Lin WC,Chen JH

更新日期：2015-06-01 00:00:00

abstract：:Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...

journal_title：Translational oncology

authors： Myung JK,Cho HJ,Kim H,Park CK,Lee SH,Choi SH,Park P,Yoon JM,Park SH

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non-small cell lung cancer (NSCLC) patients; however, the detection materials' availability remains challenging in clinical practice. In this study, we collected surgical resection tissues, lymph node biopsy, and cy...

journal_title：Translational oncology

authors： Han X,Zhang Z,Wu D,Shen Y,Wang S,Wang L,Liu Y,Yang S,Hu X,Feng Y,Sun Y,Shi Y

更新日期：2014-12-01 00:00:00

abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

journal_title：Translational oncology

authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

更新日期：2014-10-24 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00

abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

journal_title：Translational oncology

authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:The present study compared the effect of combination therapy using human apolipoprotein(a) kringle V (rhLK8) to conventional chemotherapy with paclitaxel for human ovarian carcinoma producing high or low levels of vascular endothelial growth factor (VEGF). MATERIALS AND METHODS:Human ovarian carcinoma cel...

journal_title：Translational oncology

authors： Yu HK,Lee HJ,Yun SJ,Lee SJ,Langley RR,Yoon Y,Yi LS,Bae DS,Kim JS,Kim SJ

更新日期：2014-06-17 00:00:00

abstract：:Fasting reduces gastrointestinal cellular proliferation rates through G1 cycle blockade and can promote cellular protection of normal but not cancer cells through altered cell signaling including down-regulation of insulin-like growth factor 1 (IGF-1). Consequently, the purpose of this study was to determine the effec...

journal_title：Translational oncology

authors： Withers SS,Kass PH,Rodriguez CO Jr,Skorupski KA,O'Brien D,Guerrero TA,Sein KD,Rebhun RB

更新日期：2014-05-12 00:00:00

abstract：:We study the reproducibility of quantitative imaging features that are used to describe tumor shape, size, and texture from computed tomography (CT) scans of non-small cell lung cancer (NSCLC). CT images are dependent on various scanning factors. We focus on characterizing image features that are reproducible in the p...

journal_title：Translational oncology

authors： Balagurunathan Y,Gu Y,Wang H,Kumar V,Grove O,Hawkins S,Kim J,Goldgof DB,Hall LO,Gatenby RA,Gillies RJ

更新日期：2014-02-01 00:00:00

abstract：:ErbB-3 (HER-3) receptor is involved in tumor progression and resistance to therapy. Development of specific inhibitors impairing the activity of ErbB-3 is an attractive tool for cancer therapeutics. MP-RM-1, a murine monoclonal antibody targeting human ErbB-3, has shown anticancer activity in preclinical models. With ...

journal_title：Translational oncology

authors： Sala G,Rapposelli IG,Ghasemi R,Piccolo E,Traini S,Capone E,Rossi C,Pelliccia A,Di Risio A,D'Egidio M,Tinari N,Muraro R,Iacobelli S,Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO).

更新日期：2013-12-01 00:00:00

abstract：:Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...

journal_title：Translational oncology

authors： Lemasson B,Chenevert TL,Lawrence TS,Tsien C,Sundgren PC,Meyer CR,Junck L,Boes J,Galbán S,Johnson TD,Rehemtulla A,Ross BD,Galbán CJ

更新日期：2013-12-01 00:00:00

abstract：:Intestinal commensal bacteria have recently been shown to trigger macrophages to produce diffusible clastogens (or chromosome-breaking factors) through a bystander effect (BSE) that mediates DNA damage and induces chromosomal instability in neighboring cells. Colon macrophages appear central to colon carcinogenesis an...

journal_title：Translational oncology

authors： Yang Y,Wang X,Huycke T,Moore DR,Lightfoot SA,Huycke MM

更新日期：2013-10-01 00:00:00

abstract：:Past studies have shown that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PIB5PA), is commonly downregulated or lost in melanomas, which contributes to elevated activation of phosphatidylinositol 3-kinase (PI3K)/Akt in melanoma cells. In this report, we provide evidenc...

journal_title：Translational oncology

authors： Ye Y,Li Q,Hu WL,Tseng HY,Jin L,Zhang XD,Zhang LJ,Yang S

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this tran...

journal_title：Translational oncology

authors： Bauerschlag DO,Hilpert F,Meier W,Rau J,Meinhold-Heerlein I,Maass N,Dubois A,Sehouli J,Arnold N,Schem C,Oberg HH,Baumann K

更新日期：2013-06-01 00:00:00

abstract：:MicroRNAs are endogenous posttranscriptional modulators that negatively control the expression of their target genes and play an important role in the development and progression of many malignancies, including colorectal carcinoma. In particular, expression of microRNA-21 (miR-21) is greatly increased in chemotherapy...

journal_title：Translational oncology

authors： Yu Y,Sarkar FH,Majumdar AP

更新日期：2013-04-01 00:00:00

abstract：:The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a murine solid tumor m...

journal_title：Translational oncology

authors： Lee JC,Lee HY,Moon CH,Lee SJ,Lee WH,Cha HJ,Park S,Lee YH,Park HJ,Song HT,Min YJ

更新日期：2013-02-01 00:00:00

abstract：:The presence of circulating tumor cells (CTCs) in the blood of cancer patients may guide the use of therapy. We investigated how to evaluate a reduction in the number of CTCs after administration of therapy. CTCs were enumerated with the CellSearch system in 111 metastatic breast and 185 metastatic prostate cancer pat...

journal_title：Translational oncology

authors： Coumans FA,Ligthart ST,Terstappen LW

更新日期：2012-12-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and glo...

journal_title：Translational oncology

authors： Ovchinnikov DA,Cooper MA,Pandit P,Coman WB,Cooper-White JJ,Keith P,Wolvetang EJ,Slowey PD,Punyadeera C

更新日期：2012-10-01 00:00:00

abstract：:Therapy-induced senescence (TIS), a cytostatic stress response in cancer cells, is induced inefficiently by current anticancer agents and radiation. The mechanisms that mediate TIS in cancer cells are not well defined. Herein, we characterize a robust senescence response both in vitro and in vivo to the quinone diaziq...

journal_title：Translational oncology

authors： Ewald JA,Jarrard DF

更新日期：2012-08-01 00:00:00

abstract：:Tumor cells grow in nutrient- and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. This adaptation process commonly results in a tumor phenotype that displays a high rate of aerobic glycolysis and aggressive tumor characteristics. The glucose regulat...

journal_title：Translational oncology

authors： Mendoza EE,Pocceschi MG,Kong X,Leeper DB,Caro J,Limesand KH,Burd R

更新日期：2012-06-01 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...

journal_title：Translational oncology

authors： Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

更新日期：2012-02-01 00:00:00

abstract：:Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. It also becomes exposed on tumors cells responding to therapy. In the present study, we optically imaged exposed PS in vivo using PGN635, a novel monoclonal antibody that binds PS. The ...

journal_title：Translational oncology

authors： Zhao D,Stafford JH,Zhou H,Thorpe PE

更新日期：2011-12-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most altered in cancer, leading to a range of cellular responses including enhanced proliferation, survival, and metabolism, and is thus an attractive target for anticancer drug development. Stimulation of the PI3K pathway can be initiated by alterat...

journal_title：Translational oncology

authors： Nguyen QD,Perumal M,Waldman TA,Aboagye EO

更新日期：2011-08-01 00:00:00

abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

journal_title：Translational oncology

authors： Stearns ME,Wang M

更新日期：2011-06-01 00:00:00

abstract：:Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of PC patients, which significantly increases overall survival rates up to 30%. As a consequence, there is su...

journal_title：Translational oncology

authors： van Oosten M,Crane LM,Bart J,van Leeuwen FW,van Dam GM

更新日期：2011-04-01 00:00:00

abstract：:Ovarian cancer remains the most frequently lethal of the gynecologic cancers owing to the late detection of this disease. Here, by using human specimens and three mouse models of ovarian cancer, we tested the feasibility of nonlinear imaging approaches, the multiphoton microscopy (MPM) and second harmonic generation (...

journal_title：Translational oncology

authors： Williams RM,Flesken-Nikitin A,Ellenson LH,Connolly DC,Hamilton TC,Nikitin AY,Zipfel WR

更新日期：2010-06-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) can be controlled for years with the tyrosine kinase inhibitor imatinib but because imatinib poorly penetrates the blood-brain barrier (BBB), on occasion, the CML clone will thrive and evolve to an accelerated phase in the resulting imatinib sanctuary within the central nervous syste...

journal_title：Translational oncology

authors： Kast RE,Focosi D

更新日期：2010-02-01 00:00:00